5 October 2011 (Thursday) - Sickle Cell Disease

Patient presented with abdominal pains early on a Saturday morning

Haemoglobin                6.5   g/dl   (    11 to 15    )
White Blood Cells          11.4  10^9/l (     4 to 11    )
Platelets                  351   10^9/l (   150 to 400   )
Red Blood Cells            2.49  10^12/l(   3.8 to 4.8   )
Haematocrit                0.191 ratio  (  0.36 to 0.46  )
Mean Cell Volume           76.7  fl     (    80 to 100   )
Mean Cell Haemoglobin      26.1  pg     (    27 to 32    )
Mean Cell Haemoglobin Con  34.0  g/dl   (    32 to 36    )
Neutrophils                7.5   10^9/l (     2 to 7.5   )
Lymphocytes                2.4   10^9/l (   1.5 to 4     )
Monocytes                  1.1   10^9/l (   0.2 to 1     )
Eosinophils                0.3   10^9/l (  0.02 to 0.5   )
Basophils                  0.0   10^9/l (     0 to 0.1   )
Reticulocyte count         153.5 10^9/l (    50 to 100   )

Sickle cells ++; some target cells, occasional howell-jolly bodies. neutrophils with toxic granulation.
Referred to consultant haematologist



 

Biochemistry:

Sodium          139  mmol/L       (   133 to 146   )
Potassium       4.4  mmol/L       (   3.5 to 5.3   )
Creatinine      50   umol/L       (    49 to 90    )
GFR (estimated) >90  units=*                       
Total Protein   62   g/L          (    60 to 80    )
Albumin         34   g/L          (    35 to 50    )
Globulin        28   g/L          (    20 to 35    )
Total Bilirubin 43   umol/L       (     0 to 22    )
Alk Phos        55   U/L          (    30 to 130   )
ALT             18   U/L          (     0 to 50    )


A sickle cell test was found to be positive. Subsequent HPLC showed only a single peak in the HbS position, and no peak in the HbA position.


Final Diagnosis: Patient in Sickle Cell Crisis

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