About Us
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health.
Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists.
The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge.
The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world.
Insight on Research
First map of the neurotransmitters used in the fruit fly brain
Greg Jefferis’ group in the LMB’s Neurobiology Division, in collaboration with scientists at the Janelia Research Campus, have predicted the sign of each synapsis in the fruit fly brain.
ModelAngelo software expands cryo-EM toolkit with faster atomic model building and identification of novel proteins
Kiarash Jamali, a Ph.D. student in Sjors Scheres’ group in the LMB’s Structural Studies Division, has designed a new machine learning software capable of fast, accurate model building at atomic levels and identification of new proteins beyond previous capabilities.
Quick Links
Latest News
- Christy Russell receives General Certificate in Occupational Health and Safety
Christy Russell, Advisor for Fire and Facilities Safety in the LMB’s Health and Safety Team, discusses working towards the NEBOSH qualification. […]
- Marta Zlatic elected Fellow of the Academy of Medical Sciences
Marta Zlatic, Group Leader in the LMB’s Neurobiology Division, has been elected into the Fellowship of the Academy of Medical Sciences. Joining her is alumna Jane McKeating. […]
Latest Publications
- How to enjoy and thrive in graduate school.
Hegde, RS.
Trends Cell Biol 34(5): 349-351. (23rd May 2024) - CD8 is down(regulated) for tolerance.
Rodríguez-Rodríguez, N., Rosetti, F., Crispín, JC.
Trends Immunol [Epub ahead of print]. (22nd May 2024) - Circadian regulation of macromolecular complex turnover and proteome renewal.
Seinkmane, E., et al.
EMBO J [Epub ahead of print]. (22nd May 2024) - Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer's Disease-Relevant Tau Aggregates in Human Samples.
Böken, D., et al.
Angew Chem Int Ed Engl 63(21): e202317756. (21st May 2024) - Quantitative proteomics reveals CLR interactome in primary human cells.
Manolis, D., Hasan, S., Maraveyas, A., O'Brien, DP., Kessler, BM., Kramer, H., Nikitenko, LL.
J Biol Chem : 107399 [Epub ahead of print]. (20th May 2024) - Basal delamination during mouse gastrulation primes pluripotent cells for differentiation.
Sato, N., et al.
Dev Cell 59(10): 1252-1268.e13. (20th May 2024) - To slide or not to slide: key role of the hexasome in chromatin remodeling revealed.
Rhodes, D.
Nat Struct Mol Biol 31(5): 742-746. (20th May 2024)
See more Publications