Researchers at University of Galway have created digital babies to better understand infants’ health in their critical first 180 days of life. The team created 360 advanced computer models that simulate the unique metabolic processes of each baby. The digital babies are the first sex-specific computational whole-body models representing newborn and infant metabolism with 26 organs, six cell types, and more than 80,000 metabolic reactions. Real-life data from 10,000 newborns, including sex, birth weight and metabolite concentrations, enabled the creation and validation of the models, which can be personalised - enabling scientists to investigate an individual infant’s metabolism for precision medicine applications. The work was conducted by a team of scientists at University of Galway’s Digital Metabolic Twin Centre and Heidelberg University, led by APC Microbiome Ireland principal investigator Professor Ines Thiele. The team’s research aims to advance precision medicine using computational modelling. They describe the computational modelling of babies as seminal, as it enhances understanding of infant metabolism and creates opportunities to improve the diagnosis and treatment of medical conditions during the early days of a baby’s life, such as inherited metabolic diseases. Lead author Elaine Zaunseder, Heidelberg University, said: “Babies are not just small adults - they have unique metabolic features that allow them to develop and grow up healthy. For instance, babies need more energy for regulating body temperature due to, for example, their high surface-area-to-mass ratio, but they cannot shiver in the first six months of life, so metabolic processes must ensure the infant keeps warm. “Therefore, an essential part of this research work was to identify these metabolic processes and translate them into mathematical concepts that could be applied in the computational model. We captured metabolism in an organ-specific manner, which offers the unique opportunity to model organ-specific energy demands that are very different in infants compared to adults. “As nutrition is the fuel for metabolism, we can use breast milk data from real newborns in our models to simulate the associated metabolism throughout the baby’s entire body, including various organs. Based on their nutrition, we simulated the development of digital babies over six months and showed that they will grow at the same rate as real-world infants.” Professor Ines Thiele, study lead on the project, said: “New-born screening programmes are crucial for detecting metabolic diseases early on, enhancing infant survival rates and health outcomes. However, the variability observed in how these diseases manifest in babies underscores the urgent need for personalised approaches to disease management. “Our models allow researchers to investigate the metabolism of healthy infants as well as infants suffering from inherited metabolic diseases, including those investigated in newborn screening. When simulating the metabolism of infants with a disease, the models showed we can predict known biomarkers for these diseases. Furthermore, the models accurately predicted metabolic responses to various treatment strategies, showcasing their potential in clinical settings.” Elaine Zaunseder added: “This work is a first step towards establishing digital metabolic twins for infants, providing a detailed view of their metabolic processes. Such digital twins have the potential to revolutionise paediatric healthcare by enabling tailored disease management for each infant's unique metabolic needs.” The research was published this week in Cell Metabolism This work was led by University of Galway and completed as part of a collaboration with Heidelberg University, Heidelberg Institute for Theoretical Studies and Heidelberg University Hospital, Germany. Ends

University of Galway has announced the renewal of a special partnership with the Gaelic Players Association (GPA) to provide two full MBA Scholarships to prospective students.  The scholarships are open to professional and senior executive members of the Gaelic Players Association who meet the minimum application requirements for the MBA at J.E. Cairnes School of Business and Economics. GPA chief executive Tom Parsons said: “The two fully funded MBA scholarships provide a massive opportunity to the recipients. They have the potential to be transformational in their professional lives and help the GPA to stay true to our motto of ‘You See Players. We See People’. The development of our members away from the playing pitch is our priority, as it allows them to plan for their futures once their inter-county career comes to an end, be that by choice or by necessity. So, on behalf of players, it’s important for me to thank University of Galway for their ongoing support.”    GPA-MBA Scholar 2021 and former Galway Hurler, David Collins said: “It is critical for GAA players throughout Ireland to plan for life after sport. Completing my MBA has not only equipped me with valuable skills but also ignited my passion for leadership. I am extremely grateful to the GPA and University of Galway.”      Professor Kate Kenny, University of Galway MBA Programme Director said: “These scholarships provide transformative opportunities for GPA members. By investing in education, athletes gain valuable skills, knowledge and networks that can propel them into successful careers and prepare them for life after sport.”    The University of Galway-GPA scholarships for the MBA equip GPA members - both current and former players - with the knowledge, creativity and leadership skills needed to gain a competitive edge in the fast-evolving world of leadership and business. The MBA learning environment also offers unique opportunities to engage in active learning with programme participants and experts from leading enterprises, operating at regional, national and international level.    The scholarship recipients will join a network of MBA scholars that have gone on to excel in careers in sectors such as MedTech, Fintech, ICT, Financial Services, Healthcare, Sports Leadership, Defence Forces, Public Service, Third Sector and the European Commission.    For queries on GPA Scholarships, contact GPA’s Education Manager Brian Howard at brian.howard@gaelicplayers.com or visit universityofgalway.ie/mba.     Ends 

Tá sé fógartha ag Ollscoil na Gaillimhe go bhfuil saoráid teagaisc oscailte ar an gcampas, Seomra Galway John, atá ainmnithe in ómós don Taistealaí Éireannach iomráiteach John Ward, a rugadh agus a tógadh i gCathair na Gaillimhe. Rugadh ‘Galway John’ ar Lána an Uisce ar an mBóthar Mór, Gaillimh, an 18 Meitheamh 1913. Chreid sé go láidir i luach an oideachais. I gcomhairle le gaolta, d’oibrigh Jason Sherlock, arbh é Galway John a shin-seanathair agus alumnus de chuid Ollscoil na Gaillimhe i gcomhpháirt le foireann na hollscoile ar an tionscadal chun an seomra a ainmniú i ndiaidh Galway John.             Dúirt Jason Sherlock an méid seo a leanas: “Bhí aithne ar Galway John as a phearsantacht thaitneamhach. Bhí an-ómós ag an bpobal lonnaithe do John i gcónaí agus mheas siad gur nasc láidir a bhí ann idir na Taistealaithe agus an pobal lonnaithe. Sa lá atá inniu ann, tá an t-oideachas ríthábhachtach chun difríochtaí a chéile a thuiscint agus mar is eol do go leor Mincéirí, tá sé deacair dul chun cinn a dhéanamh in áit nach mothaíonn tú go bhfuil aon ghnó agat ann. Tá súil againn go léir, tríd an seomra ranga seo a ainmniú i ndiaidh Galway John agus scéal na Mincéirí a insint go n-aireoidh Taistealaithe na hÉireann go bhfuil áit acu ar an gcampas.”             Dúirt Uachtarán Ollscoil na Gaillimhe, an tOllamh Ciarán Ó hÓgartaigh: “Tá tábhacht ar leith ag baint le Seomra Galway John mar is tráth stairiúil é seo i saol na hOllscoile. Den chéad uair riamh, tá seomra ranga buan á thiomnú againn in ómós do Thaistealaí Éireannach, ag tabhairt aitheantas do shaothar saibhir cultúrtha agus teacht aniar Thaistealaithe na hÉireann. Nuair a bhí mé ag fás aníos, shiúil mé tríd an gcampas amhail is dá mba liom féin é. Ba mhaith liom go mbraithfeadh gach duine mar an gcéanna, go bhfuil an Ollscoil seo mar dhlúthchuid dá saol. Tá an tionscnamh seo ag teacht leis an tiomantas sin chun cuimsiú, éagsúlacht agus tuiscint a chothú inár dtimpeallacht acadúil, áit a bhfuil fáilte roimh chách.” Mar Thaistealaí Éireannach, champáil John in go leor áiteanna ar champas na hOllscoile agus gar dó, in aice le hArd-Eaglais na Gaillimhe agus Ascaill na Naoscach ina measc, chomh maith le háiteanna eile sa chathair ar nós Loch an tSáile. Tá cuid d’fhoirgnimh na hOllscoile tógtha ar thailte ina mbíodh Taistealaithe na hÉireann ag cur fúthu. Bhí an-aithne ar Galway John agus ar a bhean Bridget Ward, nó Big Biddy Ward, ar fud iarthar na hÉireann as a macántacht agus a gcuid oibre crua, agus bhí Mícheál D agus Dolores Keane i measc an iliomad cairde a bhí acu. Thaistil siad ar fud na tíre mar lánúin, ag obair agus ag saothrú a gcuid ag dul go hiondúil ó Ghaillimh, Baile Átha an Rí, Creachmhaoil, an Gort, Luimneach, Cill Airne, Mórchuaird Chiarraí, Inis, Cill Rois, an Leithinse, Dúlainn, Baile Uí Bheacháin, Cinn Mhara, Cill Cholgáin agus ar ais arís. Bhí a n-iníon Anne Sherlock ina ball de Mincéir Misle, ceann de na chéad eagraíochtaí náisiúnta a bhunaigh Mincéirí ar son na Mincéirí. Bhí cúpla ceird ag Galway John idir a bheith ina ghabha stáin agus ina ghlantóir simléir. Bhí Caintis – teanga Thaistealaithe na hÉireann – Gaeilge agus Béarla ar a thoil aige. Seanchaí den scoth ba ea John, agus bhí an-chur amach aige ar fhinscéalta agus ar bhéaloideas na hÉireann, agus d’inseodh sé scéalta agus chanadh sé amhráin faoin saol ar an mbóthar. Nuair a bhásaigh Galway John an 7 Eanáir 1981, d’fhreastail na mílte ar a shochraid in Ard-Eaglais na Gaillimhe. D’fhoilsigh go leor nuachtán tuairiscí ar Aifreann na Sochraide, áit ar fhreastail gach cineál duine idir Mhincéirí, an pobal lonnaithe, cheannairí gnó agus cathartha agus ionadaithe poiblí. Críoch