Abstract
Two new phenolic compounds, 2,4,6-trihydroxy-5-methyl-acetophenone 2-O-beta-D-glucopyranoside (3), and benzyl alcohol 7-O-(3',4',6'-tri-O-galloyl)-beta-D-glucopyranoside (8), together with eight known phenolic compounds, were isolated from the 70% aqueous acetone extract of Eucalyptus gomphocephala DC. (Myrtaceae). The isolated compounds were elucidated based on their 1H, 13C, DQF-COSY, selective 1D-TOCSY, HSQC, and HMBC NMR spectroscopic and ESI-MS data. The antioxidant effect of the phenolic compounds was tested using 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl radical and super oxide anion radical scavenging assays. The cytotoxicity of the isolated compounds was evaluated using HeLa cell line.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetophenones / chemistry
-
Acetophenones / isolation & purification*
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Drug Screening Assays, Antitumor
-
Eucalyptus / chemistry*
-
Free Radical Scavengers / chemistry
-
Free Radical Scavengers / isolation & purification*
-
Gallic Acid / analogs & derivatives*
-
Gallic Acid / chemistry
-
Gallic Acid / isolation & purification
-
Glucosides / chemistry
-
Glucosides / isolation & purification*
-
HeLa Cells
-
Humans
-
Phenols / chemistry
-
Phenols / isolation & purification*
-
Plant Extracts / chemistry
Substances
-
2,4,6-trihydroxy-5-methylacetophenone 2-O-glucopyranoside
-
Acetophenones
-
Antineoplastic Agents, Phytogenic
-
Free Radical Scavengers
-
Glucosides
-
Phenols
-
Plant Extracts
-
benzyl alcohol 7-O-(3',4',6'-tri-O-galloyl)glucopyranoside
-
Gallic Acid